Tracie White on physician and Pulitzer Prize-winning author Siddhartha Mukherjee’s insatiable quest for knowledge and his innate ability to make connections between literature, history, and science as he creates and evolves treatments for his cancer patients.

“Sid thinks big and sees big,” says Atul Gawande, ’87, himself the author of four bestselling books on medicine, a surgeon, and a friend of Mukherjee’s. “He’s able to see the entire landscape of cancer, the gene, and then the cell, and then on and on. He’s driven by understanding at the molecular level what our lives are like as an organism, and even at the societal level. That’s how he makes sense of the world.”

It’s late afternoon, and the light in Mukherjee’s office begins to fade. But Mukherjee is still thinking and talking and making plans. He talks about the art scene in New York City, visiting museums on weekends. He admits, a bit sheepishly, that he also has artistic talents. In fact, some of his obsessive doodling of molecules appears in his books. He grins. Sure, he’s obsessive about his work, but he loves his life outside the office. He and Sze throw elaborate dinner parties in their Manhattan apartment, for which he cooks. Sze describes how, when her husband likes a dish at a restaurant, he dissects it, smelling it, tasting it, talking to the chef if he can’t figure out how it was made—and then re-creates it at home. “It’s a good metaphor for how he looks at life,” Sze says. “He’s always kind of sniffing out good ideas. Always on the prowl for things to be cracked open and solved.”